Abstract
The corresponding 6-dialkyldithiocarbamoyl derivatives are obtained by reacting N,N′bis(2-R-6-chloro-5-nitro-4-pyrimidyl)-carbamates. in ont example it was shown that these products may be rearranged on heating with the formation of the bis(1,3-dithiolo[4,5-d]pyrimidyl)piperazine system, and in the presence of an alkaline catalyst may be converted by fission of the pyrimidine ring into the highly polarized N,N′-bis(1-amino-2-cyano-2-nitro-1-ethenyl)-piperidine.
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References
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Additional information
For part 1 see [1].
Center for Drug Chemistry, All-Russian Pharmaceutical Chemistry Research Institute (VNIKhFI), Moscow 119815. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 208–210, February, 1995. Original article submitted October 14, 1994.
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Makarov, V.A., sedov, A.L., Nemeryuk, M.P. et al. Investigation of bisheteryl derivatives of piperazine and its analogs. 2. Synthesis and properties of bis(dialkyldithiocarbamoyl-5-nitro-4-pyrimidyl)piperazines. Chem Heterocycl Compd 31, 180–182 (1995). https://doi.org/10.1007/BF01169676
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DOI: https://doi.org/10.1007/BF01169676