Abstract
The photooxidation of tropan derivatives by ketones was studied; the targeting of the reaction to the N-CH3 group with the formation of N-alkylation products and bis-tropan derivatives was demonstrated. The presence of two diastereomers in salts of N-alkyl derivatives of tropan was detected by PMR spectroscopy. An alternative method of synthesis of difficult-to-obtain amino alcohols was proposed.
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Scientific-Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow 125315. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 179–183, February, 1995. Original article submitted September 5, 1994.
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Kostochka, L.M., Skoldinov, A.P. & Lezina, V.P. Photoinduced N-β-hydroxyalkylation of tropan derivatives. Chem Heterocycl Compd 31, 153–156 (1995). https://doi.org/10.1007/BF01169671
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DOI: https://doi.org/10.1007/BF01169671