Abstract
A method has been developed for the synthesis of some N,N′-bis(5-nitro-6-pyrimidiny;) derivatives of piperazine and dispirotripiperazinium dichloride containing a chlorine atom in the 4 position of the pyrimidine ring. It has been shown possible to react them with various nucleophilic reagents with the formation of the corresponding dialkylamino derivatives.
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Additional information
Center for Drug Chemistry, Moscow 119815. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp, 971–975, July, 1994. Original article submitted May 30, 1994.
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Makarov, V.A., Sedov, A.L., Nemeryuk, M.P. et al. Investigation of bis-heteryl derivatives of piperazine and its analogs 1. Synthesis and conversions of n,n′-bis(2-r-5-nitro-6-pyrimidinyl)piperazines and n,n3-bis(2-r-5-nitro-6-pyrimidinyl)dispirotripiperazinium dichloride. Chem Heterocycl Compd 30, 841–845 (1994). https://doi.org/10.1007/BF01169643
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DOI: https://doi.org/10.1007/BF01169643