Abstract
The reactions of 1,2-diaminopropane, 1-amino-2-propanol, 1-amino-2-ethanol and N-(β-aminoethyl)-1,2-diaminoethane in the gas phase over copper chromite have been investigated with the objective of synthesising nitrogen containing heterocycles. At 240–360°C 1,2-diaminopropane gave principally methyl- and 2,5-dimethylpyrazine, whereas the basic reaction for 1-amino-2-propanol was dehydration to give 1-aminoethyl-2-methylaziridine (with a selectivity of up to 78%). The main cyclic product from the dehydration of 1-amino-2-ethanol was pyrazine, while piperazine was farmed together with pyrazine from N-(β-amonoethyl)-1-2-diaminoethane.
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References
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Additional information
Latvian Institute of Organic Synthesis, Riga, LV-1006. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 950–957, July, 1994.
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Meksh, P.A., Anderson, A.A. & Shimanska, M. Synthesis of nitrogen containing heterocycles over copper chromite. Chem Heterocycl Compd 30, 822–828 (1994). https://doi.org/10.1007/BF01169640
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DOI: https://doi.org/10.1007/BF01169640