Abstract
Alkylatio of 2-piperidinomethylene-2H-pyrrolo[1,2-a]indole-3,9-dione with dimethyl sulfate, followed by hydrolysis of the intermediate immonium salts. yielded 2-formyl derivatives, the reaction of which with substances possessing on active methylene unit leads to the formation of 2-substituted vinyl-3-oxo-9-alkoxypyrrolo[1,2-aindoles. Cyclization of the 9-methoxy derivative yielded a new heterocyclic system of 2-amino-3-cyano-5H-4,5-dihydropyrodol[3′2′:4,5]pyrroloindoledione-4,11.
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References
N. Z. Tugusheva, S. Yu. Ryabova, N. P. Solov'evu, and V. G. Granik, Khim. Geterotsikl. Soed., No. 6, 781 (1994).
N. Z. Tugusheva, S. Yu. Ryabova, N. P. Solov'eva, and V. G. Granik, Medeleev Commun., No. 6. 238 (1993).
G. Kalaus, N. Malkien, M. Kajtar-Peredy, T. Koritsanzky, A. Kalman, L. Szabo, and 0. Szantay, J. Org. Chem.,50, 3760 (1985).
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Center for the Chemistry of Drugs, S. Ordzhonikidze All-Russian Scientific Research Institute Moscow119021 Translated from Khimiya Geterotsiklicheskikh Soedinenii.No. 8, pp, 919–925, August, 1994. Orginally article submitted June 22, 1994.
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Tugusheva, N.Z., Ryabova, S.Y., Solov'eva, N.P. et al. Synthesis of a new heterocyclic system of 2-amino-3-cykanO-5h-4,5-dihydropyrido[3′,2′:4,5]-pyrrolo[1,2-a]indole. Chem Heterocycl Compd 30, 793–799 (1994). https://doi.org/10.1007/BF01169636
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DOI: https://doi.org/10.1007/BF01169636