Abstract
The alkylation of adenine and N(in6)-substituted adenine derivatives by 1, 2-dihaloethanes and the production of 9-(2-haloethyl)derivatives of adenine were studied. 1n the reaction of the derivatives with amino alcohols a series of adenine derivatives containing an amino alcohol fragment was synthesized.
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References
N. P. Rarnzaeva, Yu. Sh. Goldberg, É. R. Alksnis, M. Yu. Lidak, and M. V. Shimanskaya, Zh. Org. Khim.,25, 1783 (1989).
N. Ramzaeva, Yu. Goldberg, E. Alksnis, and M. Lidaks, Synth. Commun.,19, 1669 (1989).
N. Ramzaeva, Yu. Goldberg, E. Alksnis, and M. Lidaks, Synth. Commun.,19, 3121 (1989).
E. Alksnis, N. Ramzaeva, M. Lidaka, and E. Lukevics, International Conference on Environmental and Biological Aspects of Main-Group Organometals, Abstracts, Bordeaux (1994), PC8.
L. Fellows, Chem. Brit.,23, 842 (1987).
J. W. Dennis, K. Koch, S. Yuosefi, and I. Van der Elst, Cancer Res.,50, 1867 (1990).
D. T. Browne, J. Eisinger, and N. J. Leonard, J. Am. Chem. Soc.,90, 7302 (1968).
N. P. Ramzaeva, M. Yu. Lidak, Yu. Sh. Gol'dberg, and M. V. Shimanskaya, Khim. Geterotsikl. Soedin., No. 3, 113 (1987).
N. P. Ramzaeva, M. Yu. Lidak, Yu. Sh. Gol'dberg, and M. V. Shimanskaya, Zh. Org. Khim.,24, 1090 (1988).
Additional information
Latvian Institute of Organic Synthesis, Riga, LV-1006. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 386–390, March, 1996. Original article submitted March 7, 1995.
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Alksnis, É., Lidak, M. Synthesis of adenine derivatives containing an amino alcohol fragment. Chem Heterocycl Compd 32, 333–337 (1996). https://doi.org/10.1007/BF01169254
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DOI: https://doi.org/10.1007/BF01169254