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Chemistry of Heterocyclic Compounds

, Volume 32, Issue 3, pp 310–312 | Cite as

Shapiro reaction in the series of piperidine derivatives. Synthesis of 3-hydroxy-1,2,3,6-tetrahydropyridines

  • A. M. Zvonok
  • E. B. Okaev
Article

Abstract

It is shown that the reaction of tosythydrazones of 3-hydroxypiperidin-4-ones with bases, depending on the nature of the latter, results in a rearrangement with a narrowing of the heterocycle and formation of acetylpyrrolidines, or in the formation of 3-hydroxy-1,2,3,6,-tetrahydropyridines.

Keywords

Organic Chemistry Piperidine Tetrahydropyridines Piperidine Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    G. V. Grishina, S. O. Bachurin, S. E. Tkachenko, and N. S. Zefirov, Khim. Geterotsikl. Soedin., No. 7, 913 (1993).Google Scholar
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    R. H. Shapiro, Org. React.,26, 405 (1976).Google Scholar
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    A. M. Zvonok, V. 1. Biba, and L. S. Stanishevskii, Khim. Geterotsikl. Soedin., No. 10, 1344 (1988).Google Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • A. M. Zvonok
  • E. B. Okaev

There are no affiliations available

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