Chemistry of Heterocyclic Compounds

, Volume 32, Issue 3, pp 310–312 | Cite as

Shapiro reaction in the series of piperidine derivatives. Synthesis of 3-hydroxy-1,2,3,6-tetrahydropyridines

  • A. M. Zvonok
  • E. B. Okaev


It is shown that the reaction of tosythydrazones of 3-hydroxypiperidin-4-ones with bases, depending on the nature of the latter, results in a rearrangement with a narrowing of the heterocycle and formation of acetylpyrrolidines, or in the formation of 3-hydroxy-1,2,3,6,-tetrahydropyridines.


Organic Chemistry Piperidine Tetrahydropyridines Piperidine Derivative 
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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • A. M. Zvonok
  • E. B. Okaev

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