Abstract
The method of Hantzsch was used to synthesize esters and amides of 2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxylic acid, containing electron donor substituents in the phenyl ring. It was found that in addition to their antioxidant properties, 3,5-diamides and 4-(3′,4′-dioxyphenyl) derivatives have an affinity for model phospholipid membranes.
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Latvian Institute of Organic Synthesis, Riga, LV-1006. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp, 1358–1365, October, 1996. Original article submitted June 20, 1996.
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Plotnietse, M., Tirzitis, G., Uldrikis, Y. et al. Synthesis of 1,4-dihydropyridine derivatives having an oxy-, alkoxy-, or dimethylaminophenyl substituent in the 4 position, their antioxidant activity, and their binding to phospholipid membranes. Chem Heterocycl Compd 32, 1166–1172 (1996). https://doi.org/10.1007/BF01169228
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DOI: https://doi.org/10.1007/BF01169228