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Chemistry of Heterocyclic Compounds

, Volume 1, Issue 1, pp 5–7 | Cite as

N, N-bis (2-chloroethyl) amides and N, N-bis(2-chloroethyl) hydrazides of carboxylic acids of the furan series

  • B. V. Kurgan
  • S. A. Giller
  • A. A. Gruze
Article

Abstract

Reaction of N, N-bis(2-chloroethyl)amine hydrochloride with chloroanhydrides of carboxylic acids of the furan series, in chloroform in the presence of pyridine gives N, N-bis(2-chloroethyl)amides of furan carboxylic acid, furylacrylic acid, 5-nitrofuran carboxylic acid, and 5-nitrofurylacrylic acid.

N, N-bis(2-chloroethyl)hydrazides of furan carboxylic acid, furyl carboxylic acid, 5-nitrofuran carboxylic acid, and 5-nitrofurylacrylic acid were obtained in 78–88% yields by reacting N, N-bis(2-chloroethyl)hydrazine hydrochloride with the chloroanhydrides of the appropriate acids in chloroform in the presence of pyridine. The last two hydrazides were prepared in 31 % and 56 % yield, respectively, using anhydrous sodium acetate in place of pyridine.

Keywords

Chloroform Amide Pyridine Hydrochloride Carboxylic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Faraday Press, Inc. 1965

Authors and Affiliations

  • B. V. Kurgan
    • 1
  • S. A. Giller
    • 1
  • A. A. Gruze
    • 1
  1. 1.Institute of Organic Synthesis AS Latvian SSRRiga

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