Abstract
A Method of synthesis of N-(ω-trimethylsilylalkyl)purines, by alkylation of potassium salts of purine bases by 3-chloropropyltrimethylsilane and chloromethyltrimethylsilanes under conditions of interfacial catalysis, has been developed. Hydroxylation of the N-allyl group by dimethylphenylsilane, which is an alternative pathway of synthesis of silicon-containing purine derivatives, has been accomplished for the first time in the purine series. The structure of the compounds obtained was established by methods of PMR and UV spectroscopy.
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References
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Additional information
Latvian Institute of Organic Synthesis, Riga LV-1006. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 654-658, May, 1995. Original article submitted October 25, 1994.
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Alksnis, É., Lidak, M. & Kyjevits, É. Synthesis of N-(ω-trimethylsilylalkyl)purines under conditions of interfacial catalysis. Chem Heterocycl Compd 31, 577–581 (1995). https://doi.org/10.1007/BF01166333
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DOI: https://doi.org/10.1007/BF01166333