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Chemistry of Heterocyclic Compounds

, Volume 31, Issue 5, pp 553–556 | Cite as

Synthesis and psychotropic properties of azomethine derivatives of thiophene

  • L. N. Khokhlova
  • S. Germane
  • N. P. Erchak
  • É. Lukevits
Article
  • 33 Downloads

Abstract

A series of azomethine derivatives was obtained by condensation of 2-thiophenaldehyde and 5-substituted (alkyl, bromine, tert-butyl, trimethylsilyl)-2-thiophenaldehydes withsemicarbazide, thiosemicarbazide, aminohydantoin, and 2-semicarbazide acetic acid. Their psychotropic activity was investigated. It was found that incorporation of a ten-butyl group in position 5 of the thiophene ring potentiates the toxicity of the compound. 5-Trimethylsilyl-and 5-ten-butyl-2-thiophenaldehyde thiosemicarbazones exhibit elevated neurotropic activity. These compounds cause the stimulating effect of phenamine to appear, increasing the motor activity of animals by two times and prolonging the effect of hexenal-induced sleep. Substitution of thiosemicarbazone by semicarbazone decreases the activity except for hexenal sleep, where the 5-tert-butyl-2-thiophenaldehyde semicarbazone was 1.5 times more active than the thiosemicarbazone.

Keywords

Acetic Acid Hexenal Motor Activity Bromine Thiophene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • L. N. Khokhlova
  • S. Germane
  • N. P. Erchak
  • É. Lukevits

There are no affiliations available

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