Abstract
3′,5′-Substituted arabinofuranosyluracil is a starting compound in 2′-modifications. A convenient and effective method is proposed for the synthesis of 1-(3′,5′-di-o-trityl-β-D-arabinofuranosyl)uracil by successive reactions of 2,2′-cyclization of uridine, 3′,5′-tritylation of the 2,2′-anhydrouridine, and hydrolytic cleavage of the 2,2′-anhydro bond.
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Additional information
Institute of Organic Synthesis, Riga LV-1006. Odense Universitet, Kemisk Institut, Odense, Denmark. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 975–977, July, 1996. Original article submitted April 25, 1996.
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Zablotskaya, A., Segal, I. & Pedersen, E.V. Simple and effective method for the synthesis of 3′,5′-substituted 1-β-D-arabinofuranosyluracil. Chem Heterocycl Compd 32, 835–837 (1996). https://doi.org/10.1007/BF01165730
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DOI: https://doi.org/10.1007/BF01165730