Chemistry of Heterocyclic Compounds

, Volume 32, Issue 2, pp 210–211 | Cite as

Synthesis of aryl-substituted benzo[α]quinolizines by the cyclocondensation of cyclic azomethines with arylidenenmalonates

  • A. L. Mikhal'chuk
  • O. V. Gulyakevich
  • A. A. Akhrem


Reactions of enamines, showing nucleophilic properties, with electrophilic olefins are known, and the investigated synthetic method is utilized in detail for the synthesis of various carbo- and heterocyclic compounds (1, 21. A typical example of this reaction is the synthesis of benzo[a]quinolizines [3–5], including compounds of practical importance such as emetine and its analogs (6, 71. Nevertheless, it should be noted that far from all questions of the practical utilization of this reaction have been resolved at the present time. In particular, the limits of the applicability of this reaction have still not been determined, which does not allow the practicable evaluation of its synthetic potential and the effective utilization in the preparative synthesis of compounds of practical importance.


Organic Chemistry Practical Importance Heterocyclic Compound Synthetic Method Practical Utilization 
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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • A. L. Mikhal'chuk
    • 1
  • O. V. Gulyakevich
    • 1
  • A. A. Akhrem
    • 1
  1. 1.Institute of Bioorganic ChemistryAcademy of Sciences (AN) of BelarusMinsk

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