Chemistry of Heterocyclic Compounds

, Volume 32, Issue 2, pp 206–209 | Cite as

Reaction of 3-cyanopyridine-2(1H)-thiones with N-butyllithium

  • N. G. Frolova
  • V. K. Zav'yalova
  • V. P. Litvinov


The reaction of 3-cyanopyridine-2(1 H)-thiones with BuLi in ether was studied. It was found that the metallation proceeds initially at the sulfur atom. The resulting lithium salts add a second equivalent of n-butyllithium at the CN group. The hydrolysis of the dilithium derivatives leads to 3 pentanoylpyridine-2(IH)-thiones.


Sulfur Ether Hydrolysis Lithium Organic Chemistry 
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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • N. G. Frolova
    • 1
  • V. K. Zav'yalova
    • 1
  • V. P. Litvinov
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryRussian Academy of Sciences (RAN)Moscow

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