Abstract
A method has been developed for the synthesis of the angiotensin-converting enzyme inhibitor N-[1-benzyloxycarbonyl-2-(R, S)-ethoxycarbonyl-4-pyrrolidinyl]-alanylproline by the condensation of N-benzyloxy-carbonyl4-ketoproline ethyl ester with alanylproline. The intermediate Schiff's base was reduced with NaB(CN)H3. The yield of the corresponding maleate was 5.4%.
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References
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Additional information
Latvian Institute of Organic Synthesis, Riga LV-1006. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 666–667, May, 1996. Original article submitted February 13, 1996.
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Katkevich, M.Y., Sile, D.É., Korchagova, É.K. et al. Synthesis of N-[1-benzyloxycarbonyl-2-(R,S)ethoxycarbonyl-4-pyrrolidinyl]alanylproline. Chem Heterocycl Compd 32, 571–572 (1996). https://doi.org/10.1007/BF01164787
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DOI: https://doi.org/10.1007/BF01164787