Alkyl derivatives of 1-aryldihydro-4(IH,3H)-pyrimidinone-2-thiones and their structure
- 42 Downloads
The alkylation of 1-aryldihydro-4(IH,3H)-pyrimidinone-2-thiones goes through both at the thiol group and at the amide nitrogen atom of the heterocycle. Enlargement of the alkyl radical favors an increase in the portion of the N-alkyl derivative in the mixture. The influence of the folding of the heterocycle on its barrier to rotation around the Ph-N1 bond was shown.
KeywordsNitrogen Organic Chemistry Amide Thiol Nitrogen Atom
Unable to display preview. Download preview PDF.
- 1.V. Yu. Mitskyavichyus, R. S. Baltrushis, I. Ch. Bilinskaite, É. É. Liepin'sh, and R. M. Zolotoyabko, Khim. Geterotsikl. Soedin., No. 9, 1240 (1191).2Google Scholar
- 2.R. S. Baltrushis, V. Yu. Mitskyavichyus, I. Ch. Bilinskaite, R. M. Zolotoyabko, and É. É. Liepin'sh, Khim. Geterotsikl. Soedin., No. 8, 1096 (1990).Google Scholar
- 3.J. B. Lambert, Acc. Chem. Res., No. 4, 389 (1971).Google Scholar