Chemistry of Heterocyclic Compounds

, Volume 32, Issue 9, pp 1055–1057 | Cite as

Synthesis and alkylation of 6-methyl-5-phenylcarbamoyl-3-cyano-4-ethylpyridine-2(1H)thione

  • V. D. Dyachenko
  • S. G. Krivokolysko
  • V. P. Litvinov


By condensation of the anilide of acetoacetic acid, propionaldehyde, and cyanothioacetamide, 6-methyl-5-phenylcarbamoyl-3-cyano-4-ethylpyridine-2(IH)thione has been obtained. In an alkaline medium, this compound is alkylated, forming the corresponding substituted 2-pyridyl sulfides. From these pyridines, substituted thienoj2,3-blpyridines have been synthesized through the Thorpe-Ziegler reaction.


Sulfide Organic Chemistry Propionaldehyde Pyridine Alkylation 
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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • V. D. Dyachenko
  • S. G. Krivokolysko
  • V. P. Litvinov

There are no affiliations available

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