Abstract
A method was developed for the synthesis of N-substituted 2,2,6,6-tetramethyl- and 1,2,-2.6,6-pentamethyl-4-aminopiperidines starting from triacetoneamine cyanohydrin through the corresponding aminonitriles with subsequent reductive decyanation. The peculiarities of salt formation from N-substituted 4-aminopiperidines with a shielded nitrogen atom are examined.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1672–1678, December, 1971.
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Nikit-skaya, E.S., Alekseeva, L.M., Sheinker, Y.N. et al. Synthesis of N′-substituted 4-amino piperidines with a shielded nitrogen atom. Chem Heterocycl Compd 7, 1553–1559 (1971). https://doi.org/10.1007/BF01158496
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DOI: https://doi.org/10.1007/BF01158496