Abstract
This study was undertaken to evaluate the effectiveness of a new, constant low-dose, variable-length estrogen replacement therapy in preparing the endometrium of women suffering premature ovarian failure for embryo implantation. Five of 10 patients receiving the new regime became pregnant following a total of 14 embryo transfers. This study proves the efficacy of low-dosage variable-length estrogen replacement therapy for preparing the endometrium for embryo implantation in patients suffering premature ovarian failure. These studies confirm earlier observations that sequentially increasing doses of estrogen during the follicular phase are unnecessary for implantation and that the length of the follicular phase within certain undefined limits is not critical. A second important observation arising from this study concerns the relative effectiveness of the route of administration of progesterone. Five of seven patients became pregnant after receiving vaginal pessaries, compared to none of seven following intramuscular injections.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Lutjen PJ, Trounson AO, Leeton JF, Findlay JK, Wood EC, Renou PM: The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure. Nature 1984; 307:174–175
Asch R, Balmaceda J, Ord T, Borrero C, Cefalu E, Gastaldi C, Rojas F: Oocyte donation and gamete intrafallopian transfer as treatment for premature ovarian failure. Lancet 1987; 1:687
Serhal P, Craft I: Simplified treatment for ovum donation. Lancet 1987; 1:687–688
Lutjen PJ, Findlay JK, Trounson AO, Leeton JF, Chan CK: Effects on plasma gonadotrophins of cyclic steroid replacement prior to embryo transfer in women with premature ovarian failure. J Clin Endocrinol Metab 1986; 62:419–423
Cameron It, Rogers PAW, Healy DL, Leeton JF: The development of a flexible steroid replacement schedule for agonadal women undergoing in vitro fertilization using donated oocytes. Proceedings from the Fertility Society of Australia, Newcastle, 29 Aug–1 Sept, 1988
Cameron It, Rogers PAW, Salamonson LA, Healy DL: The endocrine requirements for implantation and early embryogenesis in women. J Reprod Fertil Suppl 1988; 36:17–25
Leeton J, Trounson A, Wood C: The use of donor eggs and embryos in the management of human infertility. Aust NZ J Obstet Gynaecol 1984; 24:265–270
Infertility (Medical Procedures) Act of State of Victoria, Australia, 1984, No 10163, Sect 12:10
Padwick ML, Endacott J, Matson C, Whitehead MI: Absorption and metabolism of oral progesterone when administered twice daily. Fertil Steril 1986; 46:402–407
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Leeton, J., Rogers, P., Cameron, I. et al. Pregnancy results following embryo transfer in women receiving low-dosage variable-length estrogen replacement therapy for premature ovarian failure. J Assist Reprod Genet 6, 232–235 (1989). https://doi.org/10.1007/BF01132871
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01132871