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Growth hormone—A cogonadotropin? Its role in ovulation induction

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References

  1. Adashi EY, Resnick CE, D'Ercole J, Svoboda ME, Van Wyk JJ: Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocrinol Rev 1985;6:400

    Google Scholar 

  2. Richards JS: Hormonal control of ovarian follicular development: A 1978 perspective. Recent Prog Horm Res 1979; 35:343

    PubMed  Google Scholar 

  3. Hsueh AJW, Adashi EY, Jones PBC, Welsh TH Jr: Hormonal regulation of the differentiation of cultured ovarian granulosa cells. Endocrinol Rev 1984;5:76

    Google Scholar 

  4. Van Wyk JJ: The somatomedins-biological actions and physiologic control mechanisms.In Hormonal Proteins and Peptides, CH Li (ed) Orlando, FL, Academic Press 1984, p 81

    Google Scholar 

  5. Schoenle E, Zapp J, Humbel RE, Froesch ER: Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature 1982;296:252

    PubMed  Google Scholar 

  6. Sheikholislam BM, Stempfel RS Jr: Hereditary isolated somatotropin deficiency: Effects of human growth hormone administration. Pediatrics 1972;49:362

    PubMed  Google Scholar 

  7. Homburg R, Eshel A, Abdalla HI: Growth hormone facilitates ovulation induction by gonadotropins. Clin Endocrinol (Oxf) 1988;29:113–117

    Google Scholar 

  8. D'Ercole AJ, Stiles AD, Underwood LE: Tissue concentrations of somatomedin-C: Further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci USA 1984;81:935

    PubMed  Google Scholar 

  9. Ranke MB, Stanley CA, Tenore A, Rodbard D, Bangiovanni AM, Parks JS: Characterization of somatogenic and lactogenic binding sites in isolated rat hepatocytes Endocrinology 1976;99:1033

    PubMed  Google Scholar 

  10. Rein MS, Schomberg DW: Characterization of insulin receptors on porcine granulosa cells. Biol Reprod 1982;26 (Suppl 1): 113

    Google Scholar 

  11. Ladenheim RG, Tesone M, Charreau EH: Insulin action and characterization of insulin receptors in rat luteal cells. Endocrinology 1984;115:752

    PubMed  Google Scholar 

  12. Otani T, Mauro T, Yukimur N, Mochizuki M: Effect of insulin on porcine granulosa cells: implications of a possible receptor mediated action. Acta Endocrinol 1985;108:104

    PubMed  Google Scholar 

  13. Advis JP, Ojeda SR: Activation of GH short-loop negative feedback delays puberty in the female rat. Fed Proc 1980;39:822

    Google Scholar 

  14. Advis JP, Smith-White S, Ojeda SR: Activation of growth hormone short loop negative feedback delays puberty in the female rat. Endocrinology 1981;108:1343

    PubMed  Google Scholar 

  15. Snell GD: Dwarf, a new mendelian recessive character of the house mouse. Proc Natl Acad Sci 1929;15:733

    Google Scholar 

  16. Smith PE, MacDowell EC: Hereditary anterior pituitary deficiency in mouse. Proc Natl Acad Sci 1929;15:249

    Google Scholar 

  17. Lewis UJ, Cheever EV, Vander Laan WP: Studies on growth hormone of normal and dwarf mice. Endocrinology 1965;76:210

    PubMed  Google Scholar 

  18. Cheng TC, Beamer WG, Phillips III JA, Bartke A, Mollonee RL, Dowling C: Etiology of growth hormone deficiency in Little, Ames and Snell dwarf mice. Endocrinology 1983; 113:1669

    PubMed  Google Scholar 

  19. Goodman HG, Grumbach MM, Kaplan SL: Growth and growth hormone. II. A comparison of isolated growth hormone deficiency and multiple pituitary hormone deficiencies in 35 patients with idiopathic hypopituitary dwarfism. N Engl J Med 1968;278:57

    PubMed  Google Scholar 

  20. Rabinowitz D, Merimee TJ: Isolated human growth hormone deficiency and related disorders. Isr J Med Sci 1973; 9:1599

    PubMed  Google Scholar 

  21. Tanner JM, Whitehouse RH: A note on the bone age at which patients with true isolated growth hormone deficiency enter puberty J. Clin Endocrinol Metab 1975;41:788

    PubMed  Google Scholar 

  22. Rivarola MA, Phillips JA III, Migeon CJ, Heinrich JJ, Hjellé BJ: Phenotypic heterigeneity in familial isolated growth hormone deficiency type I-A. J Clin Endocrinol Metab 1984; 59:34

    PubMed  Google Scholar 

  23. Magner JA, Rogol AD, Gorden P: Reversible growth hormone deficiency and delayed puberty triggered by a stressful experience in a young adult. Am J Med 1984;76:737

    PubMed  Google Scholar 

  24. Hammer RE, Palmiter RD, Brinster RL: Partial correction of murine bereditary growth disorder by germ-line incorporation of a new gene. Natur 1984;311:65

    Google Scholar 

  25. Bartke A: Histology of the anterior hypophysis, thyroid and of murine hereditary growth disorder by germ-line incorporation of a new gene. Nature 1984;311:65

    PubMed  Google Scholar 

  26. Dereviers MM, Viguiermartinez MC, Mariana JC: FSH. LH and prolactin levels, ovarian follicular development and ovarian responsiveness to FSH in the Snell dwarf mouse. Acta Endocrinol 1984;106:121

    PubMed  Google Scholar 

  27. Kusamo S, Shiki Y, Ichimura K, Amemiya S, Nozaki Y, Ohyama K, Kato K: The sexual development of idiopathic growth hormone deficiency—The problems of the absence of puberty of the acceleration of bone age on h GH therapy Excerpta Med Int Congr Ser 1984;652:861 (abstr 1202)

    Google Scholar 

  28. Jia XC, Kalmijn J, Hsueh AJW: Growth hormone (GH) augments the FSH induction of LH receptors in cultured granulosa cells. Presented at the 32nd Annual Meeting of the Society for Gynecologic Investigation, Phoenix, AZ, 1985, abstr 179P

  29. Jia XC, Kalmijn J, Hsueh AJW: Growth hormone directly enhances FSH-induced differentiation of cultured rat granulosa cells. 67th Endocrine Society Meeting, Baltimore, MD, 1985, abstr 819

  30. Moretti C, Fabbri A, Gnessi L, Forni L, Fraioli F, Frajese G: GHRH stimulates follicular growth and amplifies FSH-induced ovarian folliculogenesis in women with anovulatory infertility. The Endocrine Society 70th Annual Meeting. New Orleans, LA, 1988, abstr 195

  31. Davoren JB, Hsueh AJW: Growth hormone increases ovarian levels of immunoreactive somatomedin C/insulin-like growth factor Iin-vivo. Endocrinology 1986;118:888–890

    PubMed  Google Scholar 

  32. Zapf J, Rinderknecht E, Humbel RE, Froesh ER: Nonsuppressible insulin-like activity (NSILA) from human serum: recent accomplishments and their physiologic implications. Metabolism 1978;27:1803

    PubMed  Google Scholar 

  33. Phillips LS, Vassilopoulou-Sellin R: Somatomedins. N Engl J Med 1980;302:371

    PubMed  Google Scholar 

  34. Salmon WD Jr, Daughaday WH: A hormonally controlled serum factor which stimulates sulfate incorporation by cartilagein-vitro. J Lab Clin Med 1957;49:825

    PubMed  Google Scholar 

  35. Davoren JB, Hsueh AJW, Li CH: Somatomedin C augments FSH-induced differentiation of cultured rat granulosa cells. Am J Physiol 1985;249:E26

    PubMed  Google Scholar 

  36. Hammond JM, Veldhuis JD, Seale TW, Rechler MM: Intraovarian regulation of granulosa cell replication. Adv Exp Med Biol 1982;147:341

    PubMed  Google Scholar 

  37. Erickson GF, Garzo VG, Magoffin DA: Insulin-like growth factor-I regulates aromatase activity in human granulosa and granulosa luteal cells. J Clin Endocrinol Metab 1989;69:716–724

    PubMed  Google Scholar 

  38. Czech MP: Structural and functional homologies in the receptors for insulin and insulin-like growth factors. Cell 1982;31:8–10

    PubMed  Google Scholar 

  39. Rechler MM, Nissley SP: The nature and regulation of the receptors for insulin-like growth factors. Annu Rev Physiol 1985;47:425–442

    PubMed  Google Scholar 

  40. Gates GS, Bayer S, Seibel M, Poretsky L, Flier JS, Moses AC: Characterization of insulin-like growth factor binding to human granulosa cells obtained duringin-vitro fertilization. J Receptor Res 1987;7:885–902

    Google Scholar 

  41. Balboni GC, Vannelli GB, Barni T, Orlando C, Serio M: Transferin and somatomedin C receptors in the human ovarian follicles. Fertil Steril 1987;48:706–801

    Google Scholar 

  42. Hshueh AJW, Bicsk TA, Jia XC, Dahl KD, Fauser BCJM, Galway B, Czekala N, Pavlou SN, Papkoff H, Keene J, Boime I: Granulosa cells as hormone targets: The role of biologically active follicle-stimulating hormone in reproduction. Recent Progr Horm Res 1989;45:209–277

    PubMed  Google Scholar 

  43. Voutilainen R, Miller WL: Coordinate trophic hormone regulation of mRNAs for insulin-like growth factor II and cholesterol side-chain cleavage enzyme, P450scc, in human steroidogenic tissues. Proc Natl Acad Sci 1989;84:1590–1594

    Google Scholar 

  44. Ramasharma K, Li CH: Human pituitary and placental hormone control of human insulin-like growth factor II secretion in human granulosa cells. Proc Natl Acad Sci 1987;842643–2647

    PubMed  Google Scholar 

  45. Ramasharma K, Cabera CM, Li CH: Identification of insulin-like growth factor II in human seminal and follicular fluids. Biochem Biophys Res Commun 1986;140:536–542

    PubMed  Google Scholar 

  46. McNatty KP, Moore-Smith D, Osathanodh R, Ryan KJ: The human antral follicle; Functional correlates of growth and atresia. Ann Biol Anim Biochem Biophys 1979;19:1547–1558

    Google Scholar 

  47. Blumenfeld Z, Lunenfeld B: The potentiating effect of growth hormone on follicle stimulation with human menopausal gonadotropin in a panhypopituitary patient. Fertil Steril 1989;52:328–331

    PubMed  Google Scholar 

  48. Rönnberg L, Martikainen H, Tapanainen J: Is there any benefit to use growth hormone in ovarian hyperstimulations? Gynecol Endocrinol (Suppl 1) 1990:4:27 (abstr)

    Google Scholar 

  49. Volpe A, Coutkos G, Barreca A, Artini PG, Minuto F, Giordano G, Genazzani AR: Ovarian response to combined growth hormone-gonadotropin treatment in patients resistant to induction of superovalation. Gynecol Endocrinol 1989;4:125–134

    Google Scholar 

  50. Miki N, Ono M, Shizume K: Evidence that opiatergic and adrenergic mechanisms stimulate rat growth hormone release via growth hormone-reliasing factor (GRF). Endocrinology 1984;114:1950–1952

    PubMed  Google Scholar 

  51. Gil-Ad I, Koch Y: Effect of clonidine on growth hormone-releasing hormone (GHRH) and somatostatin content in the rat hypothalamus during puberty. Annual Meeting of the Israel Endocrine Soc, 1989, p 10 (abstr)

  52. Tapanainen P, Knip M, Lautala P, Leppäluoto J: Variable plasma growth hormone (GH)-releasing hormone and GH responses to clonidine, L-dopa, and insulin in normal men. J Clin Endocrinol Metab 1988;67:845–849

    PubMed  Google Scholar 

  53. Homburg R, West C, Torresani T, Jacobs HS: Co-treatment with human growth hormone and gonadotropins for induction of ovulation: A controlled clinical trial. Fertil Steril 53:254–260

  54. Owen EJ, Shoham Z, Mason B, Torresani T, Jacobs HS: Addition of growth hormone to Buserelin and human gonadotropins for superovulation during IVF cycles. The IInd International Symposium on GnRH-Analogues in Cancer and Human Reproduction, Geneva, Switzerland, November 18–21, 1990

  55. Blumenfeld Z, Mait T, Barkey RJ, Lunenfeld B, Brandes JM: The synergistic effect of growth hormone and gonadotropins in achievement of conceptions in “clonidine negative” patients with unexplained infertility. The VIIth World Congress on Human Reproduction, Helsinki, Finland, June 25–July 1, 1990, abstr 159

  56. Caspi E, Ron-El R, Golan A, Nachum H, Herman A, Soffer Y, Weinraub Z: Results ofin-vitro fertilization and embryotransfer by combined long-acting gonadotropin-releasing hormone analog D-Trp-6-luteinizing hormone-releasing hormone and gonadotropins. Fertil Steril 1989;51:95–99

    PubMed  Google Scholar 

  57. Friedman AJ, Rein MS, Pandian MR, Barbieri RL: Fasting serum growth hormone and insulin-like growth factor-I and-II concentrations in women with leiomyomata uteri treated with leuprolide acetate or placebo. Fertil Steril 1990;53:250–253

    PubMed  Google Scholar 

  58. Norstedt G, Levinovitz A, Eriksson H: Regulation of uterine insulin-like growth factor-I mRNA and insulin-like growth factor II mRNA by estrogen in the rat. Acta Endocrinol (Copenh) 1989;120:466

    Google Scholar 

  59. Suikkari AM, Jalkanen J, Koistinen R, Bützow R, Ritvos C, Ranta T, Seppälä M: Human granulosa cells synthesize low molecular weight insulin-like growth factor-binding protein. Endocrinology 1989;124:1088

    PubMed  Google Scholar 

  60. Olsson JH, Carlsson B, Hillensjö T: Effect of insulin-like growth factor I on deoxyribonucleic acid synthesis in cultured human granulosa cells. Fertil Steril 1990;54:1052–1057

    PubMed  Google Scholar 

  61. Ibrahim ZHZ, Matson PL, Buck P, Lieberman BA: The use of biosynthetic human growth hormone to augment ovulation induction with buserelin acetate/human menopausal gonadotropin in women with a poor ovarian response. Fertil Steril 1991;55:202–204

    PubMed  Google Scholar 

  62. Short RV: Steroids in the follicular fluid and the corpus luteum of the mare. A “two-cell type” theory of ovarian steroid synthesis. J Endocrinol 1962;24:59–63

    PubMed  Google Scholar 

  63. Gore-Langton RE, Armstrong DT: Follicular steroidogenesis and its control.In The Physiology of Reproduction. E. Knobil, JD Neil (eds). New York. Raven Press, 1990, pp 331–385

    Google Scholar 

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  1. Reproductive Endocrinology & Infertility Section, Department of Obstetrics & Gynecology, Rambam Medical Center, and Faculty of Medicine, Technion, Israel Institute of Technology, 31096, Haifa, Israel

    Zeev Blumenfeld

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Blumenfeld, Z. Growth hormone—A cogonadotropin? Its role in ovulation induction. J Assist Reprod Genet 8, 127–136 (1991). https://doi.org/10.1007/BF01131701

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