Fallopian replacement of eggs with delayed intrauterine insemination (FREDI): An alternative to gamete intrafallopian transfer (GIFT)
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This report contains details of what is the first group of patients with nontubal infertility to undergo fallopian replacement of eggs with delayed intrauterine insemination (FREDI). Twenty-three patients suffering from idiopathic or immune infertility, polycystic ovarian disease (PCOD), or mild endometriosis underwent follicular stimulation with human menopausal gonadotropin and/or pure follicle-stimulating hormone plus human chorionic gonadotropin prior to laparoscopic pickup of eggs of varying maturity. Eggs without spermatozoa were transferred at the time of laparoscopy. Subsequent high intrauterine insemination (IUI) of washed spermatozoa at a time when egg maturation within the tubes was judged to be complete enabled a cohort of fully capacitated spermatozoa to meet fully mature eggs in a totally physiological manner. Eight clinical pregnancies arose from this group, one healthy, male infant has been delivered, and four pregnancies remain ongoing. Although based on a small population of patients, it does seem that in vivo egg maturation following replacement in the fallopian tube is an effective alternative to in vitro maturation and, with the increased control over timing of egg insemination, leads us to propose FREDI as a flexible new therapeutic approach for the treatment of nontubal infertility.
Key Wordsinfertility gamete intrafallopian transfer (GIFT) artificial insemination egg maturity
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- 4.Mollroy D, Speirs A, Du Plessis Y, McBain J, Johnston I: A laparoscopic approach to a program of gamete intrafallopian transfer. Fertil Steril 1987;48:289–294Google Scholar
- 6.Devroey P, Braeckmans P, Smitz J, Van Waesberghe L, Wisanto A, Van Steirteghem AC, Heytens L, Camu P: Pregnancy after translaparoscopic zygote intrafallopian transfer in a patient with sperm antibodies. Lancet 1986;1:1329Google Scholar
- 7.Yovich JL, Blackledge DG, Richardson PA, Edirisinghe WR, Matson PL, Turner SR, Draper R: PROST for ovum donation. Lancet 1987;1:1209Google Scholar
- 8.Leung CKM, Leong MKH, Tucker MJ, Chan YM, Wong CJY, Chan HHY: Pregnancies from fallopian replacement of immature eggs with delayed intrauterine insemination. Hum Repord 1989;4:80–81Google Scholar
- 9.Veeck LL: Atlas of the Human Oocyte and Early Conceptus. Baltimore, Williams & Wilkins, 1986Google Scholar
- 11.Tucker MJ, Leong MKH, Leung CKM, Wong CJY, Chan HHY: Is delayed capacitation a complicating factor in the treatment of idiopathic infertility by intrauterine insemination? J Vitro Fert Embryo Transfer 1987;4:245–247Google Scholar
- 13.Pavlou C, Pampiglione J: Gamete intrafallopian transfer in a non-IVF unit. Lancet 1986;2:1152–1153Google Scholar
- 18.Tucker MJ: Peri-implantational events post IVF. Int J Fertil 1989(in press)Google Scholar
- 20.Cohen J, Fehilly CB, Hewitt J: New developments in invitro fertilization. Curr Probs Obstet Gynecol Fertil 1986; IX(5):237–238Google Scholar