Abstract
Embryo-derived platelet-activating factor (PAF) may be an important mediator of early maternal recognition of pregnancy. PAF was higher in media associated with clinical pregnancies when compared to preclinical pregnancies but not higher in pregnant vs nonpregnant groups. The production of PAF by the preimplantation embryo was not related to follicle size or embryo morphology. However, differences in PAF concentrations in the culture media were related to the age of the embryo culture medium and the developmental stage of the embryo.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Rogers PAW, Milne BJ, Trounson AO: A model to show human uterine receptivity and embryo viability following ovarian stimulation for in vitro fertilization. J Vitro Fert Embryo Transfer 1986;1:93–98
O'Neill C, Gridley-Baird AA, Pike IL, Porter RN, Sinosich MJ, Saunders DM: Maternal blood platelet physiology and luteal phase endocrinology as a means of monitoring preand postimplantation embryo viability following in vitro fertilization. J Vitro Fert Embryo Transfer 1985;2:87–93
O'Neill C: Thrombocytopenia is an initial maternal response to fertilization in the mouse. J Reprod Fert 1985;73:559–566
O'Neill C: Examination of the cause of early pregnancyassociated thrombocytopenia in mice. J Reprod Fert 1985; 73:567–577
O'Neill C: Partial characterization of the embryo-derived platelet-activating factor in mice. J Reprod Fertil 1985; 75:375–380
Spinks NR, O'Neill C: Embryo-derived platelet-activating factor is essential for establishment of pregnancy in the mouse. Lancet 1987;1:106–107
Spinks NR, O'Neill C: Antagonists of embryo-derived platelet-activating factor prevent implantation in the mouse. J Reprod Fertil 1988;84:89–98
Acker G, Hecquet F, Etienne A, Braquet P, Mencia-Huerta JM: Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: Effect of the specific PAF-acether antagonist, BN 52021. Prostaglandins 1988;35:233–241
Acker G, Braquet P, Mencia-Huerta JM: Role of platelet-activating factor (PAF) in the initiation of the decidual reaction in the rat. J Reprod Fertil 1989;85:623–629
Amiel ML, Duquenne C, Benveniste J, Testart J: Platelet aggregating activity in human embryo culture media free of PAF-acether. Hum Reprod 1989;4(3):327–330
Veeck LL: Oocyte assessment and biological performance. NY Acad Sci 1988;541:259–274
Pinckard RN, Farr RS, Hanahan DJ: Physicochemical and Functional identity of rabbit platelet activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils. J Immunol 1979;123: 1847–1857
O'Neill C, Gridley-Baird AA, Pike IL, Saunders DM: Use of a bioassay for embryo-derived platelet activating factor as a means of assessing quality and pregnancy potential of human embryos. Fertil Steril 1987;47:969–975
Angle MJ, Jones MA, McManus LM, Pinckard RN, Harper MJK: Platelet-activating factor in the rabbit uterus during early pregnancy. J Reprod Fertil 1988;83:711–722
Blank ML, Lee TC, Fitzgerals V, Snyder FJ: Biol Chem 1982;256:175–178
Blank ML, Hall MN, Cress EA, Snyder F: Inactivation of 1-alkyl-2-acetyl-sn-glycero-3 phosphocholine by plasma acetylhydrolase: Higher activities in hypertensive rats. Biochem Biophys Res Commun 1983;113:666–671
O'Neill C, Collier M, Ryan JP: Embryo-derived platelet-activating factor. J Reprod Fertil Suppl 1989;37:19–27
O'Neill C, Collier M, Ammit AJ, Ryan JP, Saunders DM, Pike IL: Supplementation of in vitro fertilization culture medium with platelet-activating factor. Lancet 1989;30:769–771
O'Flaherty JI, Redman JF Jr, Schmitt JD: 1-O-Alkyl-2-n-methylcarbamyl-glycophosphocholine: A biologically potent, non-metabolizable analogue of platelet activating factor. Biochem Biophys Res Commun 1987;147:18–24
O'Neill C: Embryo-derived platelet activating factor. V World Congress on in vitro fertilization and embryo transfer, Norfolk, VA, 1987 PS-040 (abstr)
O'Neill C: Embryo-derived platelet-activating factor: A preimplantation embryo mediator of maternal recognition of pregnancy. Domest Anim Endocrinol 1987;4:69–85
O'Neill C: PAF: An essential embryonic antocoid and an initial mediator of maternal recognition of pregnancy. Society for Gynecologic Investigation, Scientific Program and Abstracts, 36th Annual Meeting, 1989, pp 38–39
Harper MJK, Kudolo GB, Alecozay AA, Jones MA: Platelet-activating factor (PAF) and blastocystendometrial interactions.In Development of Preimplantation Embryos and Their Environment, Prog Clin Biol Res 294; K Yoshinaga, T Mosi (eds) New York, Alan R Liss, 1989, pp 305–315
Kudolo GB, Harper MJK: Binding parameters of rabbit uterine PAF-receptors: Pilot study. Biol Reprod 1988;38:153 (abstr 314)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Punjabi, U., Vereecken, A., Delbeke, L. et al. Embryo-derived platelet activating factor, a marker of embryo quality and viability following ovarian stimulation for in vitro fertilization. J Assist Reprod Genet 7, 321–326 (1990). https://doi.org/10.1007/BF01130583
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01130583