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Short-term use of gonadotropin-releasing hormone agonist (Leuprolide) for in vitro fertilization

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Abstract

A common problem encountered by in vitro fertilization (IVF) programs is the premature occurrence of the spontaneous lutenizing hormone (LH) surge during ovarian stimulation cycles. Administration of gonadotropin-releasing hormone agonists (GnRH-a) for 2 to 3 weeks produces a state of hypogonadotropic hypogonadism, thus allowing ovarian stimulation to proceed uncomplicated by a spontaneous LH surge. We have elected to treat seven patients with GnRH-a in a “short-term” protocol, with GnRH-a initiated on cycle day 3 along with exogenous gonadotropins. In this series, we found that the spontaneous LH surge was abolished, while ovarian responsiveness seemed to be improved. These results suggest that the initial surge of gonadotropins elicited by GnRH-a administration may enhance ovarian stimulation and that spontaneous LH surge is blocked when GnRH-a and exogenous gonadotropins are initiated concomitantly.

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References

  1. Lemay A, Metha AE, Tolis G, Faure N, Labrie F, Fazekas AT: Gonadotropins and estradiol responses to a single intranasal or subcutaneous administration of a luteinizing hormone-releasing hormone agonist in the early follicular phase. Fertil Steril 1983;39:668

    Google Scholar 

  2. Kenigsberg D, Littman DA, Hodgen CV: Medical hypophysectomy. I. Dose-response using a gonadotropin-releasing hormone antagonist. Fertil Steril 1984;42:114

    Google Scholar 

  3. Porter RN, Smith W, Craft IL, Abdulwahid NA, Jacobs HS: Induction of ovulation for in vitro fertilization using Buserelin and gonadotropins. Lancet 1984;2:1284

    Google Scholar 

  4. Neveu S, Hedon B, Bringer J, Chinchole JM, Arnal F, Humeau C, Cristol P, Viala JL: Ovarian stimulation by a combination of a gonadotropin-releasing hormone agonist and gonadotropins for in vitro fertilization. Fertil Steril 1987;47:639

    Google Scholar 

  5. Katayama KP, Gunnarson C, Roesler MR, Stehlik E: In preparation

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Authors and Affiliations

  1. Waukesha Memorial Hospital, 725 American Avenue, 53188, Waukesha, Wisconsin

    K. Paul Katayama & Mark Roesler

  2. Advanced Institute of Fertility, Good Samaritan Medical Center, 2000 West Kilbourn Avenue, 53233, Milwaukee, Wisconsin

    Cindy Gunnarson, Ed Stehlik & Susan Jagusch

Authors
  1. K. Paul Katayama
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  2. Mark Roesler
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  3. Cindy Gunnarson
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  4. Ed Stehlik
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  5. Susan Jagusch
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Katayama, K.P., Roesler, M., Gunnarson, C. et al. Short-term use of gonadotropin-releasing hormone agonist (Leuprolide) for in vitro fertilization. J Assist Reprod Genet 5, 332–334 (1988). https://doi.org/10.1007/BF01129568

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  • DOI: https://doi.org/10.1007/BF01129568

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