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Chemistry of Heterocyclic Compounds

, Volume 1, Issue 2, pp 122–127 | Cite as

Synthesis in the fields of 5-nitrofuryl-2-polyalkenals and 5-nitrofuryl-2-polyalkenones. VII. Synthesis and investigation of the antibacterial properties of derivatives of α,β-unsaturated and polyene aldehydes and ketones of the 5-nitrofuran series

  • S. A. Giller
  • S. P. Zaeva
  • K. K. Venter
  • L. N. Alekseeva
  • L. V. Kruzmetra
  • S. K. Germane
Article
  • 49 Downloads

Abstract

Antibacterial properties and toxicities were determined for 66 compounds of the 5-nitrofuran type to ascertain the connection between structure and biological activity.

Unsaturated 5-nitrofuran aldehydes and some of their simplest derivatives (acetals, acylals) have high antibacterial activity and a broad spectrum. However, these compounds cannot be used in medicine because of their appreciable toxicities and low stabilities. One of the α,β-unsaturated ketones in this series, 5-nitrofurfurylideneacetone, has a broad antibacterial spectrum combined with lower toxicity. Low-toxicity derivatives of 1-aminohydantoin and 3-amino-2-oxazolid-2-one are among the imino derivatives of high antibacterial activity investigated.

Keywords

Acetal Toxicity Organic Chemistry Aldehyde Biological Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Faraday Press, Inc. 1966

Authors and Affiliations

  • S. A. Giller
    • 1
  • S. P. Zaeva
    • 1
  • K. K. Venter
    • 1
  • L. N. Alekseeva
    • 1
  • L. V. Kruzmetra
    • 1
  • S. K. Germane
    • 1
  1. 1.Institute of Organic Synthesis AS Latvian SSRRiga

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