Abstract
The reaction of esters of amino acids with 4-amino-6-chloro-5-nitropyrimidine has yielded esters of (4-amino-5-nitro-6-pyrimidyl)amino acids. The reduction of the esters of α-(4-amino-5-nitro-6-pyrimidylamino) acids has yielded 4-amino-6-hydroxy-7,8-dihydropteridines. α-(4-Amino-5-nitro-6-pyrimidylamino) acids and the ester of N-(4-amino-5-nitro-6-pyrimidyl)-β-alanine do not cyclize and on reduction give the corresponding diaminopyrimidine derivatives.
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References
V. M. Cherkasov, G. S. Tret'yakova, N. A. Kapran, and N. A. Nedel'kina, KhGS [Chemistry of Heterocyclic Compounds],3, 170, 1967.
M. Polonovski and H. Jirome, C. r.,230, 392, 1950.
J. Clark and A. Layton, J. Chem. Soc., 3411, 1959.
W. Boon, W. Jones, and G. Ramage, J. Chem. Soc., 96, 1951.
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Cherkasov, V.M., Kapran, N.A., Tret'yakova, G.S. et al. Synthesis and reduction of esters of N-(4-amino-5-nitro-6-pyrimidyl)amino acids. Chem Heterocycl Compd 5, 98–100 (1969). https://doi.org/10.1007/BF01031780
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DOI: https://doi.org/10.1007/BF01031780