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Chemistry of Heterocyclic Compounds

, Volume 5, Issue 1, pp 58–60 | Cite as

Synthesis of acetyltrialkylpyrroles from 2, 4-pentanediones

  • Yu. E. Sklyar
  • R. P. Evstigneeva
  • N. A. Preobrazhenskii
Article
  • 33 Downloads

Abstract

The condensation of isonitrosoacetylacetone with 3-alkyl-2,4-pentanediones and reduction with zinc in acetic acid givesα-acetyltrialkylpyrroles. The analogous condensation of 3-alkyl-3-nitroso-2,4-pentanediones with acetylacetone leads toβ-acetyltrialkylpyrroles, and condensation with acetoacetic ester leads toβ-ethoxycarbonyltrialkylpyrroles. When theα- andβ-acetyltrialkylpyrroles undergo salt formation, the oxygen of the carbonyl group is protonated.

Keywords

Oxygen Acetic Zinc Ester Acetic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Consultants Bureau 1971

Authors and Affiliations

  • Yu. E. Sklyar
    • 1
  • R. P. Evstigneeva
    • 1
  • N. A. Preobrazhenskii
    • 1
  1. 1.Lomonosov Moscow Institute of Precision Chemical EngineeringUSSR

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