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Chemistry of Heterocyclic Compounds

, Volume 5, Issue 1, pp 46–48 | Cite as

Alkylation of aminothiazoles

VII. Alkylation of 2-aminothiazole and 2-amino-4-methylthiazole with tert-butyl alcohol
  • V. A. Krasovskii
  • S. I. Burmistrov
Article

Abstract

The alkylation of 2-aminothiazole and 2-amino-4-methylthiazole with ten-butyl alcohol in sulfuric acid has been repeated. In correction of preceding information, it has been found that alkylation takes place in position 5 of the thiazole ring and not at the amino group. The presence of a primary amino group in the alkylation products was shown by the production of arylsulfonyl derivatives soluble in alkalies and of 2-halothiazoles by the Sandmeyer replacement of the amino group by halogen. Alkylation with alkyl halides yielded the corresponding thiazolone imides.

Keywords

Alcohol Organic Chemistry Sulfuric Acid Alkylation Halide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    V. A. Krasovskii and S. I. Burmistrov, KhGS [Chemistry of Heterocyclic Compounds],3, 154, 1967.Google Scholar

Copyright information

© Consultants Bureau 1971

Authors and Affiliations

  • V. A. Krasovskii
    • 1
  • S. I. Burmistrov
    • 1
  1. 1.Dnepropetrovsk Chemical and Technological InstituteUSSR

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