Skip to main content
SpringerLink
Log in

Bronchopulmonary dysplasia in premature infants A radiological and pathological correlation

  • Originals
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

In a group of 70 premature and newborn infants, treated with artificial ventilation, 24.3% developed bronchopulmonary dysplasia (BPD). Only in very few cases did the typical radiological stages, as described by Northway, succeed each other in a chronological order. It is impossible to differentiate BPD stage I or II from RDS stage III and IV without a knowledge of the clinical course and of the duration of artificial ventilation. The lower the gestational age, the more severe and earlier do the radiological and histological changes occur. The radiological differential diagnosis of BPD includes Wilson-Mikity-syndrome, congenital pulmonary lymphangiectasia, neonatal tuberculosis, cystic fibrosis and Hamman-Richsyndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Berg, T.J., Pagtakhan, R. D., Reed, M.H., Langston, C., Chernick, V.: Bronchopulmonary dysplasia and lung rupture in hyaline membrane disease: influence of continuous distending pressure. Pediatrics55, 51 (1975)

    PubMed  Google Scholar 

  2. Bryan, M.H., Hardie, M.J., Reilly, B. J., Swyer, P.R.: Pulmonary function studies during the first year of life in infants recovering from the respiratory distress syndrome Pediatrics52, 169 (1973)

    PubMed  Google Scholar 

  3. de Lemos, R., Wolfsdorf, J., Nachman, R., Block, A.J., Leiby, G., Wilkonson, H., Allen, T., Haller, J.A., Morgan, W., Avery, M.E.: Lung injury from oxygen in lambs. Anaesthesiology30, 609 (1969)

    Google Scholar 

  4. Donohue, W.L., Laski, B., Uchida, I., Munn, J.D.: Familial fibrocystic pulmonary dysplasia and its relation to the Hamman-Rich-syndrome Pediatrics23, 786 (1959)

    Google Scholar 

  5. Harrod, J.R., L'Heureux, P., Wangensteen, O.D., Hunt, C.E.: Longterm follow-up of severe respiratory distress syndrome treated with IPPB. J. Pediat.84, 277 (1974)

    PubMed  Google Scholar 

  6. Ivemark, B.I., Wallgren, C.G.: Diffuse interstitial pulmonary fibrosis (Hamman-Rich-syndrome) in infancy. Acta paediat. scand. Suppl.135, 97 (1962)

    Google Scholar 

  7. Johnson, J.D., Malachowski, N.C., Grobstein, R., Welsh, D., Daily, W.J.R., Sunshine, P.: Prognosis of children surviving with the aid of mechanical ventilation in the newborn period. J. Pediat.84, 272 (1974)

    PubMed  Google Scholar 

  8. Kapanci, Y., Robinson, F., Kaplan, E.: Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys. II. Ultrastructural and morphometric studies. Lab. Invest.20, 101 (1969)

    PubMed  Google Scholar 

  9. Kaplan, H., Robinson, F., Kapanci, Y.: Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys I. Clinical and light microscopic studies. Lab. Invest.20, 94 (1969)

    PubMed  Google Scholar 

  10. Klaus, M., Faranoff, A.: Respiratory problems. In: M. Klaus, A. Faranoff: Care of the high-risk neonate. Philadelphia, London, Toronto: W. B. Saunders Co. 1973

    Google Scholar 

  11. Laupus, W.E.: Bronchopulmonary dysplasia. In: E. L. Kendig: Pulmonary disorders, Vol. I. Philadelphia, London, Toronto: W.B. Saunders Co. 1972

    Google Scholar 

  12. Mikity, V.G., Taber, P.: Complications in the treatment of respiratory distress syndrome: Bronchopulmonary dysplasia, oxygen toxicity and the Wilson-Mikity-syndrome. Pediat. Clin. N. Amer.20, 419 (1973)

    PubMed  Google Scholar 

  13. Nash, G., Blennerhassett, J. B., Pontoppidan, H.: Pulmonary lesions associated with oxygen therapy and artificial ventilation. New Engl. J. Med.276, 368 (1967)

    PubMed  Google Scholar 

  14. Noonan, J.A., Walters, L.R., Reves, J.T.: Congenital pulmonary lymphangiectasis. Amer. J. Dis. Child.120, 314 (1970)

    PubMed  Google Scholar 

  15. Northway, W.H., Rosan, R. C., Porter, D.Y.: Pulmonary disease following respirator therapy of hyaline membrane disease: bronchopulmonary dysplasia. New Engl. J. Med.276, 357 (1967)

    PubMed  Google Scholar 

  16. Northway, W.H., Rosan, R.C.: The radiographic features of pulmonary oxygen toxicity in the newborn: bronchopulmonary dysplasia. Radiology91, 49 (1968)

    PubMed  Google Scholar 

  17. O'Hara, E., Libshitz, H.I.: Congenital pulmonary lymphangiectasis. Amer. J. Roentgenol.103, 119 (1968)

    PubMed  Google Scholar 

  18. Outerbridge, E.W., Stern, L.: Developmental follow-up of artificially ventilated infants with neonatal respiratory failure. Pediat. Res.6, 152 (1972)

    Google Scholar 

  19. Philip, A.G.S.: Oxygen plus pressure plus time: The etiology of bronchopulmonary dysplasia. Pediatrics55, 44 (1975)

    PubMed  Google Scholar 

  20. Reynolds, E.O.R., Taghizadeh, A.: Improved prognosis of infants mechanically ventilated for hyaline membrane disease. Arch. Dis. Childh.49, 505 (1974)

    PubMed  Google Scholar 

  21. Rhodes, P.G., Hall, R.T., Leonidas, J.C.: Chronic pulmonary disease in neonates with assisted ventilation. Pediatrics55, 788 (1975)

    PubMed  Google Scholar 

  22. Robinson, F.R., Harper, D.T., Thomas, A.S., Kaplan, H.P.: Proliferative pulmonary lesions in monkeys exposed to high concentrations of oxygen. Aerospace Med.38, 481 (1967)

    Google Scholar 

  23. Shannon, M.P., Grantmyre, E.B., Reid, W.D., Wotherspoon, A.S.: Congenital pulmonary lymphangiectasis. Pediat. Radiol.2, 235 (1974)

    Google Scholar 

  24. Shepard, F.M., Johnston, R.B., Klatte, E.C., Burko, H., Stahlman, M.: Residual pulmonary findings in clinical hyaline-membrane disease. New Engl. J. Med.279, 1063 (1968)

    PubMed  Google Scholar 

  25. Siassi, B., Emmanouilides, G.C., Cleveland, R.J., Hirose, F.: Patent ductus arteriosus complicating prolonged assisted ventilation in respiratory distress syndrome. J. Pediat.74, 11 (1969)

    PubMed  Google Scholar 

  26. Tsai, S.H., Anderson, R., Strickland, M.B., Pliego, M.: Bronchopulmonary dysplasia associated with oxygen therapy in infants with respiratory distress syndrome. Radiology105, 107 (1972)

    PubMed  Google Scholar 

  27. Wesenberg, L.R.: The newborn chest. New York, Evanston, San Francisco, London: Harper & Row, Publishers 1973

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pediatric Radiology and Neonatology, University Children's Hospital, Heidelberg, FRG

    H. C. Oppermann, L. Wille & M. Obladen

  2. Institute of Pathology Department of Clinical Medicine, University of Heidelberg, Mannheim, FRG

    U. Bleyl

  3. Röntgenabteilung, Universitäts-Kinderklinik, Im Neuenheimer Feld 150, D-6900, Heidelberg 1, Federal Republic of Germany

    H. C. Oppermann

Authors
  1. H. C. Oppermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Wille
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. U. Bleyl
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Obladen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Oppermann, H.C., Wille, L., Bleyl, U. et al. Bronchopulmonary dysplasia in premature infants A radiological and pathological correlation. Pediatr Radiol 5, 137–141 (1977). https://doi.org/10.1007/BF00973978

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00973978

Key words

Search

Navigation