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Investigation of lactams.

XXVI. “Transamination” of enamines ofα-oxolactams and new synthesis ofα-amino-caprolactam

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

α-Substituted lactams, including the syn (IIa, b) and anti (IIIa, b) isomers ofα-oxo- and N-methyl-α-oxocaprolactam phenylhydrazones, were synthesized by reaction of enamines ofα-oxolactams (I) with hydrazine, phenyl- and 4-pyrimidylhydrazines, thiosemicarbazide, and hydroxylamine. A new synthesis ofα-aminocaprolactam was accomplished by hydrogenation of enamine Ia over Raney nickel in an alcohol solution of ammonia.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, Moscow

    R. G. Glushkov, V. G. Smirnova, I. M. Zasosova & I. M. Ovcharova

Authors
  1. R. G. Glushkov
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  2. V. G. Smirnova
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  3. I. M. Zasosova
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  4. I. M. Ovcharova
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Additional information

See [1] for communication XXV.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 798–801, June, 1975.

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Glushkov, R.G., Smirnova, V.G., Zasosova, I.M. et al. Investigation of lactams.. Chem Heterocycl Compd 11, 696–699 (1975). https://doi.org/10.1007/BF00959965

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  • DOI: https://doi.org/10.1007/BF00959965

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