Abstract
The condensation of 1-(p-alkoxyphenyl)-1-aminomethylcyclopentanes with dimethoxyphenylacetic acid has given the corresponding amides (III) which were isolated in the form of two isomers. The Bischler-Napieralski cyclization of the amides XIII converted them into 7-alkoxy-1-(3′, 4′-dimethoxybenzyl)-4-spirocyclopentane-3,4-dihydroisoquinolines (V), and reduction with the aid of lithium aluminum hydride into the amines IV. The reduction of the dihydroisoquinolines V gave the tetrahydro derivatives VI.
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A. L. Mndzhoyan, E. A. Markaryan, T. M. Martirosyan, and S. S. Vasilyan, KhGS [Chemistry of Heterocyclic Compounds],5, 529, 1969.
E. R. Shepard and J. F. Noth, J. Am. Chem. Soc.,72, 4364, 1950.
E. R. Shepard, H. D. Porter, J. F. Noth, and C. K. Simans, J. Org. Chem.,17, 568, 1952.
S. I. Sergievskaya, K. V. Levshina, A. I. Gavrilova, and A. K. Chizhov, ZhOKh,28, 1845, 1958.
A. L. Mndzhoyan and M. G. Tsinker, Arm. khim. zh., 20, 1967.
M. Protiva, Z. Vejdelek, and M. Rajsher, Coll.,28, 629, 1963.
A. L. Mndzhoyan, E. A. Markaryan, N. E. Akopyan, and L. P. Solomina, Izv. AN ArmSSR, KhN,18, 397, 1965.
L. Bellamy, Infrared Spectra of Complex Molecules [Russian translation], IL, Moscow, p. 243, 1957.
V. N. Nikitin and N. A. Sharapova, ZhSKh,7, 538, 1966.
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For part I, see [1].
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Mndzhoyan, A.L., Markaryan, É.A., Solomina, L.P. et al. Isoquinoline derivatives. Chem Heterocycl Compd 5, 612–614 (1969). https://doi.org/10.1007/BF00957371
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DOI: https://doi.org/10.1007/BF00957371