Abstract
A number of pyrimido[5,4-b]quinoline derivatives were synthesized. It is shown that in the reaction of 2,4,10-trichloropyrimido[5,4-b]quinoline (II) with strong nucleophilic reagents (OCH3 and SH) both of the halogens of the pyrimidine ring are replaced, while with amines substitution of the halogens of the pyrimidine ring proceeds successively; under more severe conditions, all three halogen atoms of II are replaced by amine residues.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
N. E. Britikova, L. A. Belova, O. Yu. Magidson, and A. S. Elina, Khim. Geterotsikl. Soedin., 131 (1974).
H. C. Koppel, R. H. Springer, R. K. Robins, and C. C. Cheng, J. Org. Chem.,27, 181 (1962).
G. D. Daves, F. Baiocchi, R. K. Robins, and C. C. Cheng, J. Org. Chem.,26, 2775 (1961).
E. M. Levine and T. I. Bardos, J. Heterocycl. Chem.,9, 91 (1972).
Author information
Authors and Affiliations
Additional information
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 554–557, April, 1974.
Rights and permissions
About this article
Cite this article
Britikova, N.E., Belova, L.A. & Elina, A.S. Study of the nucleophilic substitution reactions of 2,4,10-trichloropyrimido[5,4-b]quinoline. Chem Heterocycl Compd 10, 482–484 (1974). https://doi.org/10.1007/BF00945647
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00945647