Abstract
2-Amino-3-ethoxycarbonyl-4-arylthiophene derivatives are aminomethylated with bisdimethylaminomethane and bisdiethylaminomethane to give a number of Mannich bases.
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References
H. D. Hartough, S. J. Lukasiewicz, and E. H. Murray, J. Am. Chem. Soc.,68, 1389, 1946.
H. D. Hartough, S. J. Lukasiewicz, and E. H. Murray, J. Am. Chem. Soc.,70, 1146, 1948.
V. I. Shvedov, V. K. Ryzhkova, and A. N. Grinev, author's certificate 180608, 1965; Byull izobr., no. 8, 24, 1966.
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Shvedov, V.I., Ryzhkova, V.K. & Grinev, A.N. Aminomethylation of derivatives of 2-amino-3-ethoxycarbonyl 4-arylthiophene. Chem Heterocycl Compd 3, 359–360 (1967). https://doi.org/10.1007/BF00945364
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DOI: https://doi.org/10.1007/BF00945364