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Condensation of 1,2,5-trimethyl-4-piperidone with ethyl- and naphthylacetylenes and synthesis of substituted pyridines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The Favorskii reaction with 1,2,5-trimethyl-4-piperidone and ethyl- and naphthylacetylenes gave the corresponding piperidols, the hydrogenation of which gave 1,2,5-trimethyl-4-nbutyl(or 2-naphthylethyl)-4-piperidols. 4-Phenyl- and 4-butyl-2,5-dimethylpyridine were condensed with formaldehyde, and some of the transformations of the resultingβ-hydroxyethyl derivatives were studied.

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Literature cited

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 349–352, March, 1973.

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Prostakov, N.S., Kholdarova, T., Pleshakov, V.G. et al. Condensation of 1,2,5-trimethyl-4-piperidone with ethyl- and naphthylacetylenes and synthesis of substituted pyridines. Chem Heterocycl Compd 9, 323–326 (1973). https://doi.org/10.1007/BF00944506

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  • DOI: https://doi.org/10.1007/BF00944506

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