Abstract
Boiling 2-methyl-4-oxo-3,4-dihydrothionaphtheno[3,2-d]-pyrimidine with phosphorus oxychloride gives 2-methyl-4-chlorothionaphtheno [3,2-d]pyrimidine (II), in which the chlorine atom is mobile. Nucleophilic substitution of the mobile chlorine atom in compound II gives the 4-ethoxy,4-(N-piperidino),4-(N4-methyl-N′-piperazino), 4-[2′-(diethylamino)ethylamino],4-3′-(diethylamino)-2-hydroxypropylamino]substituted derivatives.
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Reference
E. W. McClelland and D. W. Stammers, J. Chem. Soc., 78, 1948.
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Travin, A.I., Magidson, O.Y. Some substituted 4-aminothionaphtheno [3, 2-d] pyrimidines. Chem Heterocycl Compd 3, 54–55 (1967). https://doi.org/10.1007/BF00944258
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DOI: https://doi.org/10.1007/BF00944258