Abstract
Reaction of diketene with potassium cyanate in acetic acid gives 6-methyl-2,3-dihydro-2,4-diketo-1,3-oxazine, also formed by cyclizing acetoacetylurethane, or by treating ammonium thiocyanate with diketene in the presence of mercuric acetate. Acetylation of N-trisubstituted ureas with ketene in acetic acid gives N-alkyl derivatives of 6-methyl-2,3-dihydro-2,4-diketo-1,3-oxazine.
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References
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Gunar, V.I., Mikhailopulo, I.A., Ovechkina, L.F. et al. Synthesis of 1,3-oxazine derivatives based on diketene. Chem Heterocycl Compd 3, 34–35 (1967). https://doi.org/10.1007/BF00944253
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DOI: https://doi.org/10.1007/BF00944253