Summary
Edatrexate is an analog of methotrexate whichin vitro demonstrated activity against human colon cancer xenografts grown in nude mice. In a phase II trial, 12 patients with metastatic colorectal cancer and no prior chemotherapy were treated with Edatrexate 80 mg/m2/week for an initial period of 8 weeks. No objective responses were observed. Edatrexate is inactive against colon cancer at the dose and schedule used in this trial.
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Clamon, G.H., Riggs, C.E., Dreicer, R. et al. Phase II trial of edatrexate in patients with metastatic colorectal cancer. Invest New Drugs 13, 359–361 (1995). https://doi.org/10.1007/BF00873145
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DOI: https://doi.org/10.1007/BF00873145