Abstract
The reaction of 1,5-diketones containing a pivaloyl fragment with several nitrogen-containing nucleophiles was studied. Derivatives of 2-tert-butyl-1,4-dihydropyridine were obtained and the direction of heterocyclization upon the reaction of these diketones with primary amines containing an additional nucleophilic site was elucidated. The facile free-radical cleavage of the angular tert-butyl group was demonstrated.
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Communication 41, see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1664–1668, December, 1983.
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Kaminskii, V.A., Zabolotnova, T.V., Novikova, T.V. et al. Reactions of 1,5-diketones. 42. Synthesis of heterocycles by the reaction of 4,4-dimethyl-1-phenyl-1-(2′-oxocycloalkyl)-3-pentanones with nitrogen-containing nucleophiles. Chem Heterocycl Compd 19, 1316–1319 (1983). https://doi.org/10.1007/BF00842840
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DOI: https://doi.org/10.1007/BF00842840