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A new approach to the synthesis of 2-aminomethyl-3-phenyl-5-nitroindole

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Bromination of 2-methyl-3-phenyl-5-nitroindoles has given previously unknown 2-bromoethyl-3-phenyl-5-nitroindoles, which were converted by the Delepine reaction into 2-aminomethyl-3-phenyl-5-nitroindoles. One of these (1-methyl-2-aminomethyl-3-phenyl-5-nitroindole) was also obtained by reductive amination of 1-methyl-2-formyl-3-phenyl-5-nitroindole by the Leuckart-Wallach reaction.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021, Moscow

    É. S. Krichevskii, O. B. Romanova & A. N. Grinev

Authors
  1. É. S. Krichevskii
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  2. O. B. Romanova
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  3. A. N. Grinev
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1648–1651, December, 1983.

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Krichevskii, É.S., Romanova, O.B. & Grinev, A.N. A new approach to the synthesis of 2-aminomethyl-3-phenyl-5-nitroindole. Chem Heterocycl Compd 19, 1302–1305 (1983). https://doi.org/10.1007/BF00842836

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  • DOI: https://doi.org/10.1007/BF00842836

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