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Plasma membrane guanylate cyclase is a multimodule transduction system

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Summary

This minireview highlights the studies which suggest that guanylate cyclase is a single-component transducing system, containing distinct signaling modules in a single membrane-spanning protein. A guanylate cyclase signaling model is proposed which envisions the following sequential events: (1) a signal is initiated by the binding of the hormone to the ligand binding module; (2) the signal is potentiated by ATP at ARM; and (3) the amplified signal is finally transduced at the catalytic site. All of these signaling steps together constitute a switch, which when turned on, generates the second messenger cyclic GMP.

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Authors and Affiliations

  1. The Unit of Regulatory and Molecular Biology, Pennsylvania College of Optometry, 1200 West Godfrey Avenue, 19141, Philadelphia, Pennsylvania, USA

    R. K. Sharma & T. Duda

  2. Eye Research Institute, Oakland University, Rochester, Michigan, USA

    A. Sitaramayya

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  1. R. K. Sharma
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  2. T. Duda
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  3. A. Sitaramayya
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Sharma, R.K., Duda, T. & Sitaramayya, A. Plasma membrane guanylate cyclase is a multimodule transduction system. Amino Acids 7, 117–127 (1994). https://doi.org/10.1007/BF00814155

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  • DOI: https://doi.org/10.1007/BF00814155

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