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Interorgan metabolism of valine

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Summary

Oxidation of branched-chain amino acids, leucine, isoleucine and valine, is thought to occur primarily in muscle. Theoretically, however, it is possible for valine carbon to be converted to glucose, a process which only occurs in liver and kidney. We provide evidence that valine is oxidixed toβ-hydroxyisobutyrate in muscle, and that this intermediate is released from muscle and taken up by liver and kidney for subsequent conversion to glucose, thus conserving the gluconeogenic potential of valine.

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References

  1. Bloxam DL (1972) Br J Nutr 27: 233–247

    Google Scholar 

  2. Krebs HA, Lund P (1977) Adv Enzyme Reg 15: 375–394

    Google Scholar 

  3. Taylor RT, Jenkins WT (1966) J Biol Chem 241: 4396–4405

    Google Scholar 

  4. Pettit FH, Yeaman SJ, Reed LJ (1978) Proc Natl Acad Sci USA 75: 4881–4885

    Google Scholar 

  5. Ikeda Y, Dabrowski C, Tanaka K (1983) J Biol Chem 258: 1066–1076

    Google Scholar 

  6. Robinson WG, Nagle R, Bachhawat BK, Kupiecki FP, Coon MJ (1957) J Biol Chem 224: 1–11

    Google Scholar 

  7. Rendina G, Coon MJ (1957) J Biol Chem 225: 523–534

    Google Scholar 

  8. Robinson WG, Coon MJ (1957) J Biol Chem 225: 511–521

    Google Scholar 

  9. Goodwin GW, Rougraff PM, Davis EJ, Harris RA (1988) J Biol Chem 264: 14965–14971

    Google Scholar 

  10. Lau EP, Cochran BC, Munson L, Fall RR (1979) Proc Natl Acad Sci USA 76: 214–218

    Google Scholar 

  11. Mazumder R, Sasakawa T, Kaziro Y, Ochoa S (1962) J Biol Chem 237: 3065–3068

    Google Scholar 

  12. Cannata JJB, Focesi A Jr, Mazumder R, Warner RC, Ochoa S (1965) J Biol Chem 240: 3249–3257

    Google Scholar 

  13. Tanaka K, Rosenberg LE (1983) In: Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease. McGraw-Hill, New York, pp 440–473

    Google Scholar 

  14. Hutson SM, Harper AE (1981) Am J Clin Nutr 34: 173–183

    Google Scholar 

  15. Harris RA, Paxton R (1985) Fed Proc 44: 305–315

    Google Scholar 

  16. Buffington CK, DeBuysere MS, Olson MS (1979) J Biol Chem 254: 10453–10458

    Google Scholar 

  17. Spydevold O (1979) Eur J Biochem 97: 389–394

    Google Scholar 

  18. Letto J, Brosnan JT, Brosnan ME (1990) Biochem Cell Biol 68: 260–265

    Google Scholar 

  19. Kasperek GJ, Dohm GL, Snider RD (1985) Am J Physiol 248: R166-R171

    Google Scholar 

  20. Wohlt JE, Clark JH, Derrig RG, Davis CL (1977) J Dairy Sci 60: 1875–1882

    Google Scholar 

  21. Wagenmakers AJM, Salden HJM, Veerkamp JH (1985) Int J Biochem 17: 957–965

    Google Scholar 

  22. Rougraff PM, Paxton R, Kuntz MJ, Crabb DW, Harris RA (1988) J Biol Chem 263: 327–331

    Google Scholar 

  23. Randle PJ (1983) Phil Trans R Soc (Lond) B 302: 47–57

    Google Scholar 

  24. Letto J, Brosnan ME, Brosnan JT (1986) Biochem J 240: 909–912

    Google Scholar 

  25. Landaas S (1975) Clin Chim Acta 64: 143–154

    Google Scholar 

  26. Aftring RP, Manos PN, Buse MG (1985) Metabolism 34: 702–711

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Biochemistry, Memorial University of Newfoundland, St. John's, A1B 3X9, Newfoundland, Canada

    M. E. Brosnan & J. Letto

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  1. M. E. Brosnan
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  2. J. Letto
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This research was supported by grants from the Medical Research Council of Canada and the Canadian Diabetes Association.

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Brosnan, M.E., Letto, J. Interorgan metabolism of valine. Amino Acids 1, 29–35 (1991). https://doi.org/10.1007/BF00808088

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  • DOI: https://doi.org/10.1007/BF00808088

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