Summary
The latest results concerning the asymmetric synthesis ofβ-amino acids are reviewed, focussing on methodology involving 1,4-addition of nitrogen nucleophiles toα,β-unsaturated esters. Approaches using both homochiral auxiliaries bound to the enoate and homochiral ammonia equivalents are included as well as alkylations and aldol reactions of enolates derived from homochiralβ-amino acids.
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Sewald, N. Stereoselective synthesis ofβ-amino acids via conjugate addition of nitrogen nucleophiles toα,β-unsaturated esters — Recent advances. Amino Acids 11, 397–408 (1996). https://doi.org/10.1007/BF00807944
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DOI: https://doi.org/10.1007/BF00807944