Summary
In order to investigate the proper peptide backbone conformation able to elicit a biological activity, HCO-Met-Pro-Phe-OMe, HCO-Met-Ψ[COO]Leu-Phe-OMe, and HCO-Met-OLeu-Phe-OMe, analogues of the prototypical chemotactic peptide HCO-Met-Leu-Phe-OMe, were studied by CD and IR techniques. The results obtained comparing biological and conformational data evidence the critical presence of (i) the NH group at position 2, (ii) a rather flexible backbone, (iii) the chemical structure of the central residue which can affect the stability of a possible active conformer.
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Vertuani, G., Boggian, M., Breveglieri, A. et al. Conformational studies of chemotactic HCO-Met-Leu-Phe-OMe analogues. Amino Acids 9, 375–383 (1995). https://doi.org/10.1007/BF00807274
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DOI: https://doi.org/10.1007/BF00807274