Summary
Own investigations on in-vivo tumor metabolism of the malignant human colon tumor showed a significant uptake of branched chain amino acids by the tumor itself. To study the quantitative tumor protein metabolism (“compartment “tumor”) the13C-leucine-tracer-technique was modified.
Beside the common13C-leucine-breath-test we measured also the AV-differences of13C-leucine,13C-ketoisocaproate and13CO2. The “Tumorblood flow” was measured by “venous-outflow-technique” as well as the tumor mass.
In this way it is possible to get quantitative results in substrate exchange of branched chain amino acids in malignant human colon tumors.
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Hagmüller, E., Günther, H.J., Saeger, H.D. et al. 13C-Leucine-tracer-technique for in-vivo measurement of amino acids' metabolism by human colon carcinomas. Amino Acids 1, 283–287 (1991). https://doi.org/10.1007/BF00806927
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DOI: https://doi.org/10.1007/BF00806927