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Effect of tryptophan and 5-hydroxytryptophan on the blood pressure of patients with mild to moderate hypertension

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Summary

Chronic treatment with L-tryptophan (4 g/day) reduced mean blood pressure in 8 of 9 patients with mild to moderate essential hypertension. No significant side effects of treatment were observed. An additional group of 8 patients was treated chronically with L-5-hydroxytryptophan (800 mg/day), the immediate precursor of serotonin. Five of the 8 patients had a significant reduction in mean arterial pressure. No significant side effects of treatment were observed. The reduction of blood pressure accompanying treatment with L-5-hydroxytryptophan suggests that at least a portion of the antihypertensive effect of L-tryptophan is mediated via serotonin.

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Authors and Affiliations

  1. Department of Medicine and Physiology, College of Medicine, University of Florida, Box J274, 32610, Gainesville, FL, USA

    J. R. Cade, M. J. Fregly & M. Privette

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  1. J. R. Cade
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  2. M. J. Fregly
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  3. M. Privette
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Cade, J.R., Fregly, M.J. & Privette, M. Effect of tryptophan and 5-hydroxytryptophan on the blood pressure of patients with mild to moderate hypertension. Amino Acids 2, 133–142 (1992). https://doi.org/10.1007/BF00806084

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  • DOI: https://doi.org/10.1007/BF00806084

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