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Amino Acids

, Volume 2, Issue 3, pp 225–232 | Cite as

Oral NG-nitro-L-arginine in conscious dogs: 24 hour hypertensive response in relation to plasma levels

  • S. Huber
  • J. G. Grohs
  • S. Schwarzacher
  • G. Raberger
Article
  • 30 Downloads

Summary

Haemodynamic changes after oral administration of 30 mg/kg NG-nitro-L-arginine (L-NNA) were studied in conscious chronically instrumented mongrel dogs throughout a 24 h observation period in order to evaluate the long-term efficacy of L-NNA-induced inhibition of endothelium-dependent relaxation and its relation to plasma L-NNA level. Diastolic blood pressure remained elevated for the entire 24 h observation period, but systolic blood pressure was raised only up to the 6 h value. The hypertensive response was accompanied by bradycardia. The increase in blood pressure and the plasma L-NNA level both reached their maxima at 3 h. The plasma L-NNA level at the end of the observation period was diminished by only 21.7% with respect to the maximum increase, whilst the maximum increase in mean arterial blood pressure was attenuated by 72.2% at 24 h. These data show a dissociation between plasma L-NNA level and the respective blood pressure.

Keywords

Amino acids NG-Nitro-L-arginine High performance liquid chromatography Endothelium-derived relaxing factor Blood pressure Conscious dogs 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • S. Huber
    • 1
  • J. G. Grohs
    • 1
  • S. Schwarzacher
    • 1
  • G. Raberger
    • 1
  1. 1.Department of Cardiovascular PharmacologyPharmakologisches Institut der Universität WienViennaAustria

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