Abstract
Acetylation of 2-arylamino-5-carbethoxy-6-methylnicotinonitriles gave N-acetyl-2-arylamino-5-carbethoxy-6-methylnicotinonitriles, which, under the influence of hydrogen chloride, are cyclized to 1-aryl-1,4-dihydro-6-carbethoxy-2,7-dimethyl-4-oxopyrido[2,3-d]pyrimidines. The latter can be converted to the corresponding carboxylic and hydroxamic acids, as well as to acetylation products 1-aryl-2-acetonyl-1,4-dihydro-6-carbethoxy-7-methyl-4-oxopyrido [2,3-d]pyrimidines.
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N. I. Shramm and M. E. Konshin,Khim. Geterotsikl. Soedin., No. 1, 114 (1985).
L. M. Demina, M. Yu. Gavrilov, M. I. Vakhrin, and M. E. Konshin,Khim. Geterotsikl. Soedin., No. 10, 1397 (1991).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 535–539, April, 1992.
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Deyanov, A.B., Gavrilov, M.Y. & Konshin, M.E. Synthesis and properties of 1-aryl-1,4-dihydro-2,7-dimethyl-4-oxopyrido[2,3-d]pyrimidine-6-carboxylic acids and their derivatives. Chem Heterocycl Compd 28, 449–453 (1992). https://doi.org/10.1007/BF00767010
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DOI: https://doi.org/10.1007/BF00767010