Abstract
The amination of 3-(2′-oxocyclohexyl)methylcaprolactams and -valerolactams with ammonium acetate leads to 3-(ω-aminoalkyl)-3,4,5,6,7,8-hexahydro-2-quinolones. The hydroamination of these keto lactams, as well as their oxocycloheptyl analogs, with a mixture of formamide and formic acid gives 3-(ω-aminoalkyl)peŕhydro-2-quinolones and 3-(ω-aminoalkyl)-5,6-pentamethylenetetrahydro-2-pyridones.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 525–530, April, 1992.
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Shumakov, S.A., Kaminskii, V.A. Synthesis of 3-(ω-aminoalkyl)hydro-2-quinolones and their analogs by amination and hydroamination of 3-(2′-oxocycloalkyl)methyl-substituted lactams. Chem Heterocycl Compd 28, 440–444 (1992). https://doi.org/10.1007/BF00767008
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DOI: https://doi.org/10.1007/BF00767008