Abstract
We have developed two synthesis routes for 4-amino derivatives of 6-nitro-γ-carbolines: 1) consecutive conversion of 1,2-dimethyl-3-formyl-5-nitroindole to the 3-cyano derivative, condensation of the latter with DMF diethyl acetal, and cyclization of the enamine formed in this case with ammonia and benzylamine; 2) N-oxidation of 9-substituted 6-nitro-γ-carbolines, transformation of N-oxides to the corresponding γ-carbolin-4-ones, from which the target compounds are obtained through the 4-chloro derivatives.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
V. M. Lyubchanskaya, L. S. Sarkisova, L. M. Alekseeva, and V. K. Granik,Khim. Geterotsikl. Soedin., No. 3, 357 (1992).
É. S. Krichevskii, L. M. Alekseeva, and V. G. Granik,Khim. Geterotsikl. Soedin., No. 11, 1483 (1990).
Author information
Authors and Affiliations
Additional information
For Communication 72, see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 502–505, April, 1992.
Rights and permissions
About this article
Cite this article
Krichevskii, É.S., Granik, V.G. Acetals of lactams and acid amides. 73. Synthesis and some properties of derivatives of 6-nitro-γ-carboline. Chem Heterocycl Compd 28, 420–423 (1992). https://doi.org/10.1007/BF00767002
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00767002