Abstract
Alkylation of 2,3,3-trimethyl- and 2,3,3,5-tetramethyl-3H-indoles with 2-bromomethylbenzonitrile gave 2-methylene-1-(2-cyanobenzyl)-2,3-dihydro-1H-indoles. When treated with lithium aluminum hydride the latter are cyclized to 11,12,12a,13-tetrahydro-6H-indolo[1,2-b][2,4]benzodiazepines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 815–817, June, 1990.
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Shachkus, A.A., Degutis, Y.A. & Myadyakshene, G.S. Synthesis of 11,12,12a,13-tetrahydro-6H-indolo[1,2-b]-[2,4]benzodiazepines. Chem Heterocycl Compd 26, 681–682 (1990). https://doi.org/10.1007/BF00756424
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DOI: https://doi.org/10.1007/BF00756424