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Investigation of nitrogen- and sulfur-containing heterocycles

XVII. 5H-pyridino[2,3-b]-1,4-thiazine

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

6-Carbethoxymethyl-, 7-carbethoxy-, and 6,7-dicarbethoxy-5H-pyridinothiazines were obtained by reaction of 2-mercapto-3-amino-5-chloropyridine (I) and 2-mercapto-3-amino-6-chloropyridine (H) with esters of haloketo acids in alcohol in the presence of 1 mole of KOH.α-(3-Amino-6-chloro-2-pyridyl)mercaptooxalacetic acid diethyl ester and 2-chloro-6-hydroxy-6,7-dicarbethoxy-6,7-dihydropyridino[2,3-b]-1,4-thiazine are obtained by reaction of II with chloroxalacetic ester in alcohol in the presence of 1 mole of alkali at −10°C.

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Literature cited

  1. T. S. Safonova and L. G. Levkovskaya, Khim. Geterotsikl. Soed., 1096 (1970).

  2. T. S. Safonova, M. P. Nemeryuk, L. G. Levkovskaya, and T. P. Lapshina, USSR Author's Certificate No. 245,788 (1969); Byull. Izobr., No. 20, 20 (1969).

  3. L. G. Levkovskaya and T. S. Safonova, Khim. Geterotsikl. Soed., 970 (1969),

  4. T, S. Safonova and L. G. Levkovskaya, Khim. Geterotsikl. Soed., 997 (1968).

  5. T. S. Safonova, M. P. Nemeryuk, and G. P. Syrova, Khim. Geterotsikl. Soed., 1423 (1970).

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, Moscow

    T. S. Safonova & L. G. Levkovskaya

Authors
  1. T. S. Safonova
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  2. L. G. Levkovskaya
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Additional information

For Communication XVI, see [5].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1364–1368, October, 1970.

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Safonova, T.S., Levkovskaya, L.G. Investigation of nitrogen- and sulfur-containing heterocycles. Chem Heterocycl Compd 6, 1271–1275 (1970). https://doi.org/10.1007/BF00755075

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  • DOI: https://doi.org/10.1007/BF00755075

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